Polymerases & Mixes

Development of poly ADP-ribose polymerase-1 inhibitor with anti-cervical carcinoma activity

Development of poly ADP-ribose polymerase-1 inhibitor with anti-cervical carcinoma activity

Development of poly ADP-ribose polymerase-1 inhibitor with anti-cervical carcinoma activity

This analysis aimed to find and determine new poly ADP-ribose polymerase-1 (PARP) inhibitors with potent anti-cervical carcinoma exercise, after which discover their potential organic roles on cervical carcinoma cell. For this objective, we recognized a brand new PARP inhibitor from a high-throughput digital screening technique and located that the compound strongly inhibited cervical carcinoma HeLa cell. Cell proliferation was evaluated by an MTT assay, and the cell apoptosis was assessed by stream cytometry.

Outcomes confirmed that PARP1 is a poly ADP-ribose catalyzing enzyme in eukaryotic cells, which is activated throughout DNA harm and restore, and performs an vital function in DNA restore and cell apoptosis. Herein we report the primary discovery of a brand new PARP inhibitor from a high-throughput digital screening technique, then the compound was measured its anti-cervical carcinoma exercise through the use of an MTT assay, which instructed that the compound strongly inhibited HeLa cell proliferation, the IC50 worth is 0.65 µM. As well as, the compound induced HeLa cell apoptosis in a dose-response method. All these information instructed that the compound is a promising lead compound, which deserves additional investigation. It’s concluded that the compound uncover herein is a promising PARP-1 inhibitor with potent anti-cervical carcinoma exercise, which deserves additional investigation. Individuals residing in southwest a part of United States are uncovered to uranium (U) by means of ingesting water, air, and soil. U is radioactive, however impartial of this radioactivity additionally has vital toxicological issues as an environmental metallic.

At environmentally related concentrations, U is each mutagenic and carcinogenic. Rising proof exhibits that U inhibits DNA restore exercise, however how U interacts with DNA restore proteins continues to be largely unknown. Herein, we report that U instantly interacts with the DNA restore protein, Protein Poly (ADP-ribose) Polymerase 1 (PARP-1) by means of direct binding with the zinc finger motif, leading to zinc launch from zinc finger and DNA binding exercise lack of the protein. On the peptide stage, as a substitute of direct competitors with zinc ion within the zinc finger motif, U doesn’t present thermodynamic benefits over zinc. Moreover, zinc pre-occupied PARP-1 zinc finger is insensitive to U remedy, however U certain to PARP-1 zinc finger may be partially changed by zinc. These outcomes present mechanistic foundation on molecular stage to U inhibition of DNA restore.

 

Variety and Distribution of a Novel Genus of Hyperthermophilic Aquificae Viruses Encoding a Proof-Studying Household-A DNA Polymerase

Regardless of the excessive abundance of Aquificae in lots of geothermal methods, these micro organism are tough to tradition and no viruses infecting members of this phylum have been remoted. Right here, we describe the entire, round dsDNA Uncultivated Virus Genome (UViG) of Thermocrinis Octopus Spring virus (TOSV), derived from metagenomic information, together with eight associated UViGs representing three extra viral species. Regardless of low total similarity amongst viruses from completely different scorching springs, the genomes shared a excessive diploma of synteny, and encoded quite a few genes for nucleotide metabolism, together with a PolA-type DNA polymerase polyprotein with doubtless accent features, a DNA Pol III sliding clamp, a thymidylate kinase, a DNA gyrase, a helicase, and a DNA methylase.
Additionally current had been conserved genes predicted to code for phage capsid, giant and small subunits of terminase, portal protein, holin, and lytic transglycosylase, all per a distant relatedness to cultivated Caudovirales. These viruses are predicted to contaminate Aquificae, as a number of CRISPR spacers matching the viral genomes had been recognized inside the genomes and metagenomic contigs from these micro organism. Primarily based on the anticipated atypical bi-directional replication technique, low sequence similarity to recognized viral genomes, and distinctive place in gene-sharing networks, we suggest a brand new putative genus, “Pyrovirus,” within the order Caudovirales.
 Development of poly ADP-ribose polymerase-1 inhibitor with anti-cervical carcinoma activity
Development of poly ADP-ribose polymerase-1 inhibitor with anti-cervical carcinoma activity

Growth of Improved Mumps Vaccine Candidates by Mutating Viral mRNA Cap Methyltransferase Websites within the Giant Polymerase Protein

Though a dwell attenuated vaccine is out there for controlling mumps virus (MuV), mumps nonetheless outbreaks often worldwide. The attenuated MuV vaccine pressure S79 is extensively utilized in mumps vaccination in China, however nonetheless with many shortcomings, amongst which essentially the most outstanding are the uncomfortable side effects and decreased immunity.
Subsequently, there’s a must additional enhance the protection and efficacy of the present MuV vaccine. Within the current research, we additional attenuated MuV S79 vaccine pressure by inhibiting viral mRNA methyltransferase (MTase). We generated a panel of eight recombinant MuVs (rMuVs) carrying mutations within the MTase catalytic web site or S-adenosylmethionine (SAM) binding web site within the giant (L) polymerase protein. These rMuVs are genetically steady and 7 rMuVs are extra attenuated in replication in cell tradition and 5 rMuVs are extra attenuated in replication in lungs of cotton rats in contrast with the parental vaccine pressure S79.

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 (RPAB4) Antibody

20-abx217857
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DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (RPAB1) Antibody

abx119102-100l 100 µl
EUR 312.5

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (RPAB1) Antibody

abx119102-20l 20 µl
EUR 43.75

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (RPAB1) Antibody

abx119102-50l 50 µl
EUR 237.5

DNA-directed RNA polymerases I, II, and III subunit RPABC5 (RPB10) Antibody

abx345430-01mg 0.1 mg
EUR 250

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC2 (RPAB2) Antibody

abx375529-1096tests 10 × 96 tests Ask for price

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC2 (RPAB2) Antibody

abx375529-596tests 5 × 96 tests Ask for price

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC2 (RPAB2) Antibody

abx375529-96tests 96 tests
EUR 337.5

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC3 (RPAB3) Antibody

abx375530-96tests 96 tests
EUR 337.5

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody

20-abx121663
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DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody

20-abx114604
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  • 150 ul
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DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 (POLR2K) Antibody

20-abx135780
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DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 (POLR2K) Antibody

20-abx007835
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DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody

abx036186-100ug 100 ug
EUR 469.2

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody

abx028042-400ul 400 ul
EUR 627.6

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody

abx028042-80l 80 µl
EUR 343.2

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody

20-abx001458
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DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody

20-abx304890
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  • 100 ug
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DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 (POLR2K) Antibody

20-abx304897
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  • 100 ug
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DNA-Directed RNA Polymerases I, II, And III Subunit RPABC5 (POLR2L) Antibody

abx001935-100l 100 µl
EUR 400

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC5 (POLR2L) Antibody

abx001935-20l 20 µl
EUR 175

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC5 (POLR2L) Antibody

abx001935-50l 50 µl
EUR 275

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody

abx001458-100l 100 µl
EUR 400

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody

abx001458-20l 20 µl
EUR 175

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody

abx001458-50l 50 µl
EUR 275

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody

abx114604-100l 100 µl
EUR 612.5

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC5 (POLR2L) Antibody

abx114608-100l 100 µl
EUR 612.5

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC5 (POLR2L) Antibody

abx123460-100l 100 µl
EUR 175

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC5 (POLR2L) Antibody

abx123460-1ml 1 ml
EUR 387.5

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC5 (POLR2L) Antibody

abx123460-200l 200 µl
EUR 275

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody

abx304890-100g 100 µg
EUR 362.5

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody

abx304890-20g 20 µg
EUR 162.5

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody

abx304890-50g 50 µg
EUR 250

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 (POLR2K) Antibody

abx304897-100g 100 µg
EUR 362.5

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 (POLR2K) Antibody

abx304897-20g 20 µg
EUR 162.5

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 (POLR2K) Antibody

abx304897-50g 50 µg
EUR 250

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody

abx036186-100g 100 µg
EUR 337.5

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody

abx028042-400l 400 µl
EUR 518.75

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC5 (POLR2L) Antibody

abx236628-100g 100 µg
EUR 350

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Antibody

abx237399-100g 100 µg
EUR 350

DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 (POLR2K) Antibody

abx135780-01mg 0.1 mg
EUR 175

Recombinant Human DNA-directed RNA polymerases I and III subunit RPAC2(POLR1D)

AP76802 1mg
EUR 2826

Recombinant Human DNA-directed RNA polymerases I and III subunit RPAC2 (POLR1D)

CSB-EP897095HU 4858 mg Ask for price

RNA Polymerases I/II/III Subunit ABC1 Rabbit mAb

52516 100ul
EUR 499

RNA Polymerases I/II/III Subunit ABC1 Rabbit mAb

E2R25415 100ul
EUR 255
Description: Available in various conjugation types.

Mouse DNA-directed RNA polymerases I and III subunit RPAC2 (POLR1D) ELISA Kit

EK11443 96Т
EUR 799

Mouse DNA-directed RNA polymerases I and III subunit RPAC2 (POLR1D) ELISA Kit

AE60081MO-48Tests 48 Tests
EUR 325
Description: Mouse (Mus musculus)

Mouse DNA-directed RNA polymerases I and III subunit RPAC2 (POLR1D) ELISA Kit

AE60081MO-96Tests 96 Tests
EUR 610
Description: Mouse (Mus musculus)

Mouse DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) ELISA Kit

abx543313-96tests 96 tests
EUR 687.5

Mouse DNA-directed RNA polymerases I and III subunit RPAC2 (POLR1D) ELISA Kit

abx543316-1096tests 10 × 96 tests Ask for price

Mouse DNA-directed RNA polymerases I and III subunit RPAC2 (POLR1D) ELISA Kit

abx543316-596tests 5 × 96 tests Ask for price

Mouse DNA-directed RNA polymerases I and III subunit RPAC2 (POLR1D) ELISA Kit

abx543316-96tests 96 tests
EUR 687.5

Human DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Protein

abx073376-34kDa100mg 3.4 kDa; 100 mg
EUR 325

Human DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) Protein

abx073376-5kDa100mg 5 kDa; 100 mg
EUR 225

Human DNA-directed RNA polymerases I, II, and III subunit RPABC4 (POLR2K) Protein

abx680306-100g 100 µg
EUR 225

Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) ELISA Kit

EK11441 96Т
EUR 799

Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) ELISA Kit

AE60079RA-48Tests 48 Tests
EUR 325
Description: Rat (Rattus norvegicus)

Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) ELISA Kit

AE60079RA-96Tests 96 Tests
EUR 610
Description: Rat (Rattus norvegicus)

Rat DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 (POLR2E) ELISA Kit

abx543298-96tests 96 tests
EUR 687.5

ELISA kit for Mouse DNA-directed RNA polymerases I and III subunit RPAC2 (POLR1D)

KTE71446-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Mouse DNA-directed RNA polymerases I and III subunit RPAC2 (POLR1D) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse DNA-directed RNA polymerases I and III subunit RPAC2 (POLR1D)

KTE71446-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Mouse DNA-directed RNA polymerases I and III subunit RPAC2 (POLR1D) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse DNA-directed RNA polymerases I and III subunit RPAC2 (POLR1D)

KTE71446-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Mouse DNA-directed RNA polymerases I and III subunit RPAC2 (POLR1D) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Human DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L) ELISA Kit

RK11906 96T
EUR 280

Human DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) ELISA Kit

abx543296-96tests 96 tests
EUR 687.5

Mouse DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) ELISA Kit

abx543297-96tests 96 tests
EUR 687.5

Mouse DNA-directed RNA polymerases I, II, and III subunit RPABC2 (POLR2F) ELISA Kit

abx543301-96tests 96 tests
EUR 687.5

Mouse DNA-directed RNA polymerases I, II, and III subunit RPABC3 (POLR2H) ELISA Kit

abx543304-96tests 96 tests
EUR 687.5

Human DNA-directed RNA polymerases I, II, and III subunit RPABC4 (POLR2K) ELISA Kit

abx543306-96tests 96 tests
EUR 687.5

Mouse DNA-directed RNA polymerases I, II, and III subunit RPABC4 (POLR2K) ELISA Kit

abx543307-96tests 96 tests
EUR 687.5

Mouse DNA-Directed RNA Polymerases I, II, And III Subunit RPABC5 (POLR2L) ELISA Kit

abx543310-96tests 96 tests
EUR 687.5

Human POLR2L / DNA-directed RNA polymerases I, II, and III subunit RPABC5 ELISA Kit

E14267h 96T
EUR 736

Mouse Polr2l / DNA-directed RNA polymerases I, II, and III subunit RPABC5 ELISA Kit

E14267m 96T
EUR 776

Bovine POLR2L / DNA-directed RNA polymerases I, II, and III subunit RPABC5 ELISA Kit

E14267b 96T
EUR 900

Kluyveromyces marxianus DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RPB5)

1-CSB-EP889203KAN
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  • 100ug
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Description: Recombinant Kluyveromyces marxianus DNA-directed RNA polymerases I, II, and III subunit RPABC1(RPB5) expressed in E.coli

ELISA kit for Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E)

KTE100871-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E)

KTE100871-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E)

KTE100871-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Rat DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Human RNA Polymerases I, II, III Subunit ABC3 (RPB17) Antibody

33234-05111 150 ug
EUR 215

RNA Polymerases I/II/III Subunit ABC1 Rabbit Monoclonal Antibody

E10G21864 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Recombinant Kluyveromyces marxianus DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RPB5)

CSB-EP889203KAN 4776 mg Ask for price

Recombinant Kluyveromyces marxianus DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RPB5)

RPC28314-100ug 100ug
EUR 765.5

Recombinant Kluyveromyces marxianus DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RPB5)

RPC28314-1mg 1mg
EUR 2959.2

Recombinant Kluyveromyces marxianus DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RPB5)

RPC28314-20ug 20ug
EUR 448.1

OACA01148-100UG - Rabbit anti-human DNA-directed RNA polymerases I, II, and III subunit RPABC2

OACA01148-100UG 100ug
EUR 329

Human RNA Polymerases I, II, III Subunit ABC3 (RPB17) Antibody (Biotin Conjugate)

33234-05121 150 ug
EUR 315

Human RNA Polymerases I, II, III Subunit ABC3 (RPB17) AssayLite™ Antibody (RPE Conjugate)

33234-05151 150 ug
EUR 370

Human RNA Polymerases I, II, III Subunit ABC3 (RPB17) AssayLite™ Antibody (APC Conjugate)

33234-05161 150 ug
EUR 370

Human RNA Polymerases I, II, III Subunit ABC3 (RPB17) AssayLite™ Antibody (FITC Conjugate)

33234-05141 150 ug
EUR 370

Human RNA Polymerases I, II, III Subunit ABC3 (RPB17) AssayLite™ Antibody (PerCP Conjugate)

33234-05171 150 ug
EUR 410

RNA Polymerase III Subunit C6 Rabbit pAb

E2125726 100ul
EUR 225
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

RNA Polymerase III Subunit C6 Rabbit pAb

E2825726 100ul
EUR 225
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

RNA Polymerase III Subunit G (POLR3G) Antibody

20-abx121198
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RNA Polymerase III Subunit K (POLR3K) Antibody

abx122630-100ug 100 ug
EUR 469.2

RNA Polymerase III Subunit A (POLR3A) Antibody

20-abx126391
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RNA Polymerase III Subunit F (POLR3F) Antibody

20-abx126392
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  • 100 ul
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RNA Polymerase III Subunit H (POLR3H) Antibody

20-abx133433
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  • 100 ul
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RNA Polymerase III Subunit A (POLR3A) Antibody

20-abx133710
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  • 100 ul
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RNA Polymerase III Subunit B (POLR3B) Antibody

20-abx133711
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  • 100 ul
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RNA Polymerase III Subunit E (POLR3E) Antibody

20-abx133712
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  • 100 ul
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RNA Polymerase III Subunit A (POLR3A) Antibody

20-abx114609
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  • 150 ul
  • 50 ul

RNA Polymerase III Subunit D (POLR3D) Antibody

20-abx114611
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  • 150 ul
  • 50 ul

RNA Polymerase III Subunit F (POLR3F) Antibody

20-abx114612
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  • 150 ul
  • 50 ul

RNA Polymerase III Subunit K (POLR3K) Antibody

20-abx114613
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  • 150 ul
  • 50 ul

RNA Polymerase III Subunit K (POLR3K) Antibody

20-abx007776
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  • 100 ul
  • 200 ul
  • 30 ul

RNA Polymerase III Subunit C (POLR3C) Antibody

20-abx008319
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  • 100 ul
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RNA Polymerase III Subunit F (POLR3F) Antibody

20-abx008320
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  • 100 ul
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RNA Polymerase III Subunit E (POLR3E) Antibody

abx036024-100ug 100 ug
EUR 469.2

RNA Polymerase III Subunit D (POLR3D) Antibody

abx036131-100ug 100 ug
EUR 469.2

RNA Polymerase III Subunit B (POLR3B) Antibody

abx037547-100ug 100 ug
EUR 469.2

RNA Polymerase III Subunit C (POLR3C) Antibody

abx029368-400ul 400 ul
EUR 627.6

RNA Polymerase III Subunit C (POLR3C) Antibody

abx029368-80l 80 µl
EUR 343.2
Importantly, cotton rats vaccinated with these seven rMuV mutants produced excessive ranges of serum neutralizing antibodies and had been utterly protected towards problem with a wild-type MuV pressure (genotype F). Subsequently, our outcomes show that alteration within the MTase catalytic web site or SAM binding web site in MuV L protein improves the protection or the immunogenicity of the MuV vaccine and thus mRNA cap MTase could also be an efficient goal for the event of recent vaccine candidates for MuV.

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